If you come by car from Stockholm or Arlanda Airport, follow the E4 north towards Uppsala, following the signs for Sundsvall. At Uppsala, take exit 186 towards Uppsala S and then follow the signs to the city.
If you come from Enköping, take road 55 north. When you get to Uppsala, turn right at Enköpingsvägen and continue to the city centre.
From Gävle, take the E4 south towards Uppsala/Stockholm. At Uppsala, take exit 188 towards 55/Strängnäs/288/Östhammar. At the first roundabouts, take the first exit onto Route 55/72 towards Strängnäs and then continue straight through the next roundabout you come to. From there, follow the signs in to the city.